Summary MR (SMR)

A method often applied to MR estimates which is related to the Wald ratio and often applied in analysis of gene expression on complex traits and used in conjunction with the heterogeneity in dependent instruments (HEIDI) method. 

See Wald ratio and HEIDI. 

References

• Zhu Z, Zhang F, Hu H, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics 2016; 48: 481.

Other terms in 'Two-sample MR methods':

• Inverse variance weighted (IVW) fixed effects estimate
• Maximum likelihood-based MR
• Unweighted regression
• Wald ratio estimate