A method which seeks to address if many SNPs in a single region give Wald ratio (or Ratio) estimates that are more different from each other than expected by chance under the assumption that there is a single causal variant and each SNP only exhibits an effect due to LD with the causal SNP.
This is essentially a genetic colocalization method, and a number of similar methods exist (e.g., R/coloc and S-predixscan).
- Zhu Z, Zhang F, Hu H et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nature Genetics 2016;48:481.
- Giambartolomei C, Vukcevic D, Schadt EE et al. Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics. PLOS Genetics 2014;10:e1004383.
- Barbeira AN, Dickinson SP, Bonazzola R et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nature Communications 2018;9:1825.