MR-PRESSO

This is an extension to IVW, which attempts to perform the same form of outlier removal as in GSMR and Radial MR. 

Genetic variants are removed based on their contributions to heterogeneity. It is achieved through a simulation approach. See notes on outlier removal (see also GSMR and Radial MR). 

References

• Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nature Genetics 2018;50:693-698.

Other terms in 'Heterogeneity and outlier detection methods for two-sample MR':

• Cochran's Q statistic
• HEIDI (heterogeneity in dependent instruments)
• MR-TRYX (Treasure your exceptions)
• Radial MR (MR pleiotropy residual sum and outlier)