GSMR

An R package that implements the generalized summary MR (GSMR) method to test for putative causal relationships between an exposure and outcome using summary-level data from genome-wide association studies (GWASs).

The package requires summary-level data describing the associations between the genetic variants being used as instrumental variables (IVs) and both the exposure and outcome to be obtained and input to the software by the user.

References

• Zhu Z, Zheng Z, Zhang F, et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat Commun 2018; 9: 224.

Other terms in 'Supporting resources and software packages':

• AER software package
• ivmodel
• ivonesamplemr
• ivreg2
• ivregress
• ivtools
• LD Hub
• MendelianRandomization
• MR-Base and TwoSampleMR
• MR-TRYX
• mrrobust
• OneSampleMR
• PhenoScanner
• PhenoSpD
• PHESANT
• RadialMR
• Sample size and power calculators
• Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR)