MR-TRYX

A software package in R for undertaking MR-TRYX analyses.

As the package utilises the MR-Base database (i.e., curated by the "IEU OpenGWAS"), the package allows the user to search through genome-wide association study (GWAS) databases to find candidate traits that may reflect a horizontal pleiotropic pathway between an exposure and outcome of interest. However, these databases do not have complete coverage of the human phenome and therefore unlikely to be able to completely account for the heterogeneity.

References

• Cho Y, Haycock PC, Gaunt TR, et al. MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways. bioRxiv 2018; doi: http://dx.doi.org/10.1101/476085.

Other terms in 'Supporting resources and software packages':

• AER software package
• GSMR
• ivmodel
• ivonesamplemr
• ivreg2
• ivregress
• ivtools
• LD Hub
• MendelianRandomization
• MR-Base and TwoSampleMR
• mrrobust
• OneSampleMR
• PhenoScanner
• PhenoSpD
• PHESANT
• RadialMR
• Sample size and power calculators
• Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR)