LD Hub

A database of summary-level genome-wide association study (GWAS) results and a web interface for undertaking linkage disequilibrium (LD) score regression – a method that estimates the single nucleotide polymorphism (SNP) heritability of traits (which could be health-related or disease outcomes), partitions this heritability into functional categories, and estimates the genetic correlation between different phenotypes.

Genetic correlation between two traits can be induced through the existence of a causal relationship between those two traits. Therefore, LD Hub can be used not only to automatically estimate the heritability of traits and the shared genetic architecture between two traits but also to identify plausible relationships that can be followed up using MR methodology.

References

• Zheng J, Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L, Haycock PC, et al. LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 2016; 33: 272-279.

Other terms in 'Supporting resources and software packages':

• AER software package
• GSMR
• ivmodel
• ivonesamplemr
• ivreg2
• ivregress
• ivtools
• MendelianRandomization
• MR-Base and TwoSampleMR
• MR-TRYX
• mrrobust
• OneSampleMR
• PhenoScanner
• PhenoSpD
• PHESANT
• RadialMR
• Sample size and power calculators
• Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR)