MR-Base and TwoSampleMR

A database and analytical platform for undertaking two-sample MR using summary genome-wide association study (GWAS) data. The TwoSampleMR platform enables the user to run a large number of two-sample MR analyses (including pleiotropy-robust methods) and produces numerical and graphical results.

The data (curated by the "IEU OpenGWAS" resource) and analytical platform can be accessed both online and with the TwoSampleMR R package. Users can utilize the data curated for MR-Base or their own data (the format of which is specified).

References

• Hemani G, Zheng J, Elsworth B, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 2018; 7.

Other terms in 'Supporting resources and software packages':

• AER software package
• GSMR
• ivmodel
• ivonesamplemr
• ivreg2
• ivregress
• ivtools
• LD Hub
• MendelianRandomization
• MR-TRYX
• mrrobust
• OneSampleMR
• PhenoScanner
• PhenoSpD
• PHESANT
• RadialMR
• Sample size and power calculators
• Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR)