MR GENIUS

MR G-Estimation under No Interaction with Unmeasured Selection. 

Exploits the assumption that a genetic variant is a valid instrument with respect to altering the variance rather than the mean. Genetic instrument must strongly affect the variance. 

References

• Tchetgen Tchetgen E, Sun B, Walter S. The GENIUS Approach to Robust Mendelian Randomization Inference. bioRxiv 2017:193953.

Other terms in 'Pleiotropy-robust one-sample MR methods':

• MR GxE
• PRMR
• SISVIVE
• Two-stage Hard Thresholding (TSHT) with voting