Two-stage Hard Thresholding (TSHT) with voting

TSLS applied to a subset of SNPs which are judged to be estimating the same causal effect. 

Assumes that valid SNPs form the largest set of SNPs which identify the same (true) causal effect. Requires strong genetic instruments. 

References

• Guo Z, Kang H, Cai TT, Small DS. Confidence Intervals for Causal Effects with Invalid Instruments using Two-Stage Hard Thresholding with Voting. arXiv:160305224 [mathST] 2017.

Other terms in 'Pleiotropy-robust one-sample MR methods':

• MR GENIUS
• MR GxE
• PRMR
• SISVIVE