PRMR

Pleiotropy-robust MR estimates the causal effect in the presence of pleiotropy by identifying a patient subgroup for which the genetic variant does not affect the exposure. The pleiotropic effect estimated from this subgroup is then subtracted as an offset from the TSLS estimate. 

Requires a perfect `no-relevance subgroup’. The pleiotropic effect must be constant across covariate subgroups. 

References

• van Kippersluis H, Rietveld CA. Pleiotropy-robust Mendelian randomization. Int J Epidemiol 2017.

Other terms in 'Pleiotropy-robust one-sample MR methods':

• MR GENIUS
• MR GxE
• SISVIVE
• Two-stage Hard Thresholding (TSHT) with voting