Two-stage hard thresholding (TSHT) with voting

Two-stage least squares (TSLS) applied to a subset of single nucleotide polymorphisms (SNPs) that are judged to be estimating the same causal effect. 

This method assumes that valid SNPs form the largest set of SNPs that estimate the same (true) causal effect and requires strong genetic instrumental variables (IVs). 

References

• Guo Z, Kang H, Cai TT, Small DS. Confidence Intervals for Causal Effects with Invalid Instruments using Two-Stage Hard Thresholding with Voting. arXiv:160305224 [mathST] 2017.

Other terms in 'Pleiotropy-robust one-sample MR methods':

• Adaptive Lasso
• constrained IVs
• MR for gene-environment interactions (MR-GxE)
• MR using G-Estimation under No Interaction with Unmeasured Selection (MR-GENIUS)
• Over-identification tests
• Pleiotropy-robust MR (PRMR)
• Some Invalid Some Valid Instrumental Variable Estimation (SISVIVE)