A haplotype is a version of a section of a chromosome. It describes the particular sequence of alleles of linked genetic variants found on a single chromosome.
Whilst single nucleotide polymorphisms (SNPs) are most commonly used in MR, haplotypes have also been used in one-sample MR.
References
- Ken-Dror G, Humphries SE, Kumari M, Kivimaki M, Drenos F. A genetic instrument for Mendelian randomization of fibrinogen. Eur J Epidemiol 2012; 27: 267-279.
- Brunner EJ, Kivimaki M, Witte DR, et al. Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoSMed 2008; 5: e155.
- Buxton J, Turney J. The Rough Guide to Genes & Cloning 2007.
Other terms in 'Useful genetic terms ':
- Allele
- Chromosome
- Cis- and trans-variants
- Copy number variation
- Deoxyribonucleic acid (DNA)
- Gene
- Genetic variant
- Genotype
- Heterozygous or Heterozygote
- Homozygous or Homozygote
- Linkage disequilibrium (LD)
- Locus
- Palindromic single nucleotide polymorphism (SNP)
- Polygenic risk score (PRS)
- Polymorphism
- Rare variants
- Single nucleotide polymorphism (SNP)