A haplotype is a version of a section of a chromosome. It describes the particular sequence of alleles of linked genetic variants found on a single chromosome.
Whilst SNPs are most commonly used in MR, haplotypes have also been used in one-sample MR.
References
- Ken-Dror G, Humphries SE, Kumari M, Kivimaki M, Drenos F. A genetic instrument for Mendelian randomization of fibrinogen. Eur J Epidemiol 2012;27:267-79.
- Brunner EJ, Kivimaki M, Witte DR et al. Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. PLoSMed 2008;5:e155.
- Buxton J, Turney J. The Rough Guide to Genes & Cloning 2007.