PHESANT

A tool for performing automated hypothesis-free "phenome-wide" scans in UK Biobank.

PHESANT tests the association of a specified trait (usually a genetic variant) with all continuous, integer and categorical variables in UK Biobank using a rule-based algorithm to determine how to appropriately test and model each trait, then performs the analyses and produces plots and summary tables. In relation to MR, any associations that are identified using PHESANT can then be followed up using formal MR analyses using the specified genetic variant as an instrumental variable (IV) for known exposure of interest (i.e., a trait that is known to be associated with that genetic variant).

References

• Millard LCA, Davies NM, Gaunt TR, Davey Smith G, Tilling K. Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank International Journal of Epidemiology 2018; 47: 29-35.

Other terms in 'Supporting resources and software packages':

• AER software package
• GSMR
• ivmodel
• ivonesamplemr
• ivreg2
• ivregress
• ivtools
• LD Hub
• MendelianRandomization
• MR-Base and TwoSampleMR
• MR-TRYX
• mrrobust
• OneSampleMR
• PhenoScanner
• PhenoSpD
• RadialMR
• Sample size and power calculators
• Strengthening the Reporting of Observational Studies in Epidemiology using Mendelian Randomization (STROBE-MR)