The name given to a method implemented in a particular piece of software which is similar to standard IVW but also allows for correlation between variants and seeks to remove outliers.
The MendelianRandomization package also provides utility for including the LD matrix to provide overly precise standard errors if instruments are correlated. Performance of the method is dependent on accurate estimation of the LD matrix for the samples being used.
- Zhu Z, Zheng Z, Zhang F et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat Commun 2018;9:224.