MR Dictionary

An MR method that estimates the causal effect of an exposure on an outcome in the presence of linkage disequilibrium (LD) amongst genetic variants being used as instrumental variables (IVs) and unobserved pleiotropy, without removing IVs or estimating the level of pleiotropy.

MR-Link uses summary statistics providing information about the associations between genetic variants and an exposure alongside individual-level data on the outcome to estimate the causal effect of an exposure on the outcome. The method corrects for pleiotropic effects using genetic variants that are in LD with these IVs by including the surrounding IVs as covariates in the model.


Other terms in 'Pleiotropy-robust two-sample MR methods':