Synonyms: Median-based estimate
Requires that at least 50% of the weight in the analysis stems from variants that are valid instruments. Can be either unweighted or, traditionally, weighted by the inverse variance of the SNP-outcome association but may be weighted using other methods.
- Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator. Genet Epidemiol 2016;40:304-14.