MR Dictionary

Multivariable MR (MVMR) and extensions

Multivariable MR extension of the inverse variance weighted (IVW) approach applied to either contexts using individual-level data (i.e., one-sample MR) or summary-level data (i.e., two-sample MR). This method can be used to learn about the causal effect of two or more exposures on an outcome. 

For this method to work, all exposures must be associated with at least one genetic instrumental variable (IV). All genetic IVs can be invalid IVs due to horizontal pleiotropy as long as the horizontal pleiotropy is balanced. This method can be combined with MR-Egger regression to allow for directional pleiotropy


Other terms in 'Pleiotropy-robust two-sample MR methods':