MR Dictionary

Mode-based estimate

Synonyms: Weighted mode

Defined as the mode of either an unweighted or inverse variance weighted empirical density function of the Wald ratio (or Ratio estimates). 

Requires that the largest subset of instruments which identify the same causal effect to be valid instruments. Can be either unweighted or, traditionally, weighted by the inverse variance of the SNP-outcome association but may be weighted using other methods.


Other terms in 'Pleiotropy-robust two-sample MR methods':