Synonyms: Weighted mode
Requires that the largest subset of instruments which identify the same causal effect to be valid instruments. Can be either unweighted or, traditionally, weighted by the inverse variance of the SNP-outcome association but may be weighted using other methods.
- Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. International Journal of Epidemiology 2017;46:1985-1998.