MR Dictionary

MR with penalized weights

Robust MR method developed for two-sample MR settings that downweights and excludes instrumental variables (IVs) with heterogeneous causal estimates that are likely invalid Cochran's Q statistic.

The method generates penalized weights based on the Cochran's Q statistic distribution to severly penalize IVs that have outlying causal effect estimates without downweighting genetic variants that are likely valid IVs. These penalized weights an also be applied to robust regression for both the inverse variance weighted (IVW) and MR-Egger methods, which are referred to as the robust and penalized approach (or robust regression with penalized weights). See also MR Robust and MR Lasso.


Other terms in 'Pleiotropy-robust two-sample MR methods':