MR Dictionary

Median-based estimate

Synonyms: Median-based estimate

Defined as the 50th percentile of either an unweighted or inverse variance weighted (IVW) empirical density function of the Wald ratio (or ratio estimates). 

This two-sample MR method requires that at least 50% of the weight in the analysis stems from variants that are valid instrumental variables (IVs). The estimates can be either unweighted or, traditionally, weighted by the inverse variance of the association between the single nucleotide polymorphism (SNP) and outcome but may be weighted using other methods. See NOME adjustment for more information on these types of weights.

References

Other terms in 'Pleiotropy-robust two-sample MR methods':